Carney Complex

Diagnostic criteria for Carney complex

Manifestations of disease
Required: two manifestations, or one manifestation and one supplemental criterion
Spotty skin pigmentation (typically lips, conjunctivae, canthi, genital mucosa
Cutaneous and mucosal myxomata
Cardiac myxomata
Breast myxomata
Hypercortisolism (PPNAD or paradoxical respone to dexamethasone)
Acromegaly due to GH-secreting adenoma (prolactinomas also seen)
Leydig cell tumours or testicular calcification
Thyroid carcinoma, or multiple nodules in a child
Psammomatous melanotic schwannoma
Blue nevus, epithelioid blue nevus (multiple)
Breast ductal adenomata (multiple)
Supplemental criteria
Affected first-degree relative
PRKAR1A mutation

Carney triad or syndrome

A separate entity, being the tendency of gastric epithelioid leiomyosarcomata (gastrointestinal stromal tumours - GIST), pulmonary chondromata, and extra-adrenal paragangliomata to coexist.