Post-Surgical Management of Thyroid Cancer

BTA indications for radioiodine ablation in thyroid cancer

Ablative radioiodine activity

Ablative radioiodine

Post-op follow-up

Thyroglobulin measurement

Thyroglobulin antibodies

Thyroglobulin antibodies may cause negative bias with immunochemilumimetric assays (ICMA, e.g. as used by Edinburgh), and positive bias with RIA methods (e.g. Birmingham's). Assays for Tg antibodies are in themselves inadequate to determine if a Tg result is reliable; discordant ICMA and RIA results are the most sensitive method for detecting assay interference. Even without interfering antibodies, results can vary markedly when measured by different assays - so the same assay must be used to monitor a patient.

Thyroglobulin (Tg) should therefore be measured at both Birmingham and Edinburgh with the following interpretation:

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